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Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin
The immunosuppressant and anticancer drug rapamycin works by inducing inhibitory protein complexes with the kinase mTOR, an important regulator of growth and proliferation. The obligatory accessory partner of rapamycin is believed to be FK506-binding protein 12 (FKBP12). Here we show that rapamycin...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3624267/ https://ncbi.nlm.nih.gov/pubmed/23358420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00678-12 |
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