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Why Has the Antidepressant–Placebo Difference in Antidepressant Clinical Trials Diminished over the Past Three Decades?

The increasing rate of failure of antidepressant clinical trials has led to the assertion that antidepressants do not have meaningful clinical benefits. Our hypothesis was that the decrease in antidepressant–placebo differences in antidepressant clinical trials over the past three decades could be e...

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Détails bibliographiques
Publié dans:CNS Neurosci Ther
Auteurs principaux: Khan, Arif, Bhat, Amritha, Kolts, Russell, Thase, Michael E., Brown, Walter
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6493812/
https://ncbi.nlm.nih.gov/pubmed/20406269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1755-5949.2010.00151.x
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