Evaluation of gilteritinib in combination with chemotherapy in preclinical models of FLT3-ITD(+) acute myeloid leukemia

Activating internal tandem duplication (ITD) and tyrosine kinase domain (TKD) point mutations in Fms-like tyrosine kinase 3 (FLT3) occur in approximately 30% of patients with acute myeloid leukemia (AML), and confer a poor prognosis with standard cytarabine/anthracycline or azacitidine-based chemoth...

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Publicado en:Oncotarget
Autores principales: Ueno, Yoko, Mori, Masamichi, Kamiyama, Yoshiteru, Saito, Rika, Kaneko, Naoki, Isshiki, Eriko, Kuromitsu, Sadao, Takeuchi, Masahiro
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6493465/
https://ncbi.nlm.nih.gov/pubmed/31069015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26811
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