A Minority Subpopulation of CD133(+)/EGFRvIII (+)/EGFR (−) Cells Acquires Stemness and Contributes to Gefitinib Resistance

AIMS: To study the contribution of epidermal growth factor receptor variant III (EGFRvIII) to glioblastoma multiforme (GBM) stemness and gefitinib resistance. METHODS: CD133(+) and CD133(−) cells were separated from EGFRvIII (+) clinical specimens of three patients with newly diagnosed GBM. Then, RT...

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Detalhes bibliográficos
Publicado no:CNS Neurosci Ther
Main Authors: Liu, Xu‐Jie, Wu, Wen‐Tao, Wu, Wei‐Hua, Yin, Feng, Ma, Si‐Hai, Qin, Jia‐Zhen, Liu, Xiu‐Xiu, Liu, Yi‐Nan, Zhang, Xiao‐Yan, Li, Peng, Han, Shuo, Liu, Kai‐Yu, Zhang, Jin‐Ming, He, Qi‐Hua, Shen, Li
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6493376/
https://ncbi.nlm.nih.gov/pubmed/23575351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12092
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