Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models

Flaviviruses are (re)-emerging RNA viruses strictly dependent on lipid metabolism for infection. In the search for host targeting antivirals, we explored the effect of pharmacological modulation of fatty acid metabolism during flavivirus infection. Considering the central role of acetyl-Coenzyme A c...

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Publicado en:Emerg Microbes Infect
Autores principales: Jiménez de Oya, Nereida, Esler, William P., Huard, Kim, El-Kattan, Ayman F., Karamanlidis, Georgios, Blázquez, Ana-Belén, Ramos-Ibeas, Priscila, Escribano-Romero, Estela, Louloudes-Lázaro, Andrés, Casas, Josefina, Sobrino, Francisco, Hoehn, Kyle, James, David E., Gutiérrez-Adán, Alfonso, Saiz, Juan-Carlos, Martín-Acebes, Miguel A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6493301/
https://ncbi.nlm.nih.gov/pubmed/30999821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/22221751.2019.1604084
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