Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models

Flaviviruses are (re)-emerging RNA viruses strictly dependent on lipid metabolism for infection. In the search for host targeting antivirals, we explored the effect of pharmacological modulation of fatty acid metabolism during flavivirus infection. Considering the central role of acetyl-Coenzyme A c...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Emerg Microbes Infect
Prif Awduron: Jiménez de Oya, Nereida, Esler, William P., Huard, Kim, El-Kattan, Ayman F., Karamanlidis, Georgios, Blázquez, Ana-Belén, Ramos-Ibeas, Priscila, Escribano-Romero, Estela, Louloudes-Lázaro, Andrés, Casas, Josefina, Sobrino, Francisco, Hoehn, Kyle, James, David E., Gutiérrez-Adán, Alfonso, Saiz, Juan-Carlos, Martín-Acebes, Miguel A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6493301/
https://ncbi.nlm.nih.gov/pubmed/30999821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/22221751.2019.1604084
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