Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models

Flaviviruses are (re)-emerging RNA viruses strictly dependent on lipid metabolism for infection. In the search for host targeting antivirals, we explored the effect of pharmacological modulation of fatty acid metabolism during flavivirus infection. Considering the central role of acetyl-Coenzyme A c...

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Détails bibliographiques
Publié dans:Emerg Microbes Infect
Auteurs principaux: Jiménez de Oya, Nereida, Esler, William P., Huard, Kim, El-Kattan, Ayman F., Karamanlidis, Georgios, Blázquez, Ana-Belén, Ramos-Ibeas, Priscila, Escribano-Romero, Estela, Louloudes-Lázaro, Andrés, Casas, Josefina, Sobrino, Francisco, Hoehn, Kyle, James, David E., Gutiérrez-Adán, Alfonso, Saiz, Juan-Carlos, Martín-Acebes, Miguel A.
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6493301/
https://ncbi.nlm.nih.gov/pubmed/30999821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/22221751.2019.1604084
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