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Gem Depletion: Amyotrophic Lateral Sclerosis and Spinal Muscular Atrophy Crossover

The determining factor of spinal muscular atrophy (SMA), the most common motor neuron degenerative disease of childhood, is the survival motor neuron (SMN) protein. SMN and its Gemin associates form a complex that is indispensible for the biogenesis of small nuclear ribonucleoproteins (snRNPs), whic...

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Bibliografiske detaljer
Udgivet i:CNS Neurosci Ther
Hovedforfatter: Cauchi, Ruben J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492989/
https://ncbi.nlm.nih.gov/pubmed/24645792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12242
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