TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy

BACKGROUND: Redistribution of nuclear TAR DNA binding protein 43 (TDP-43) to the cytoplasm and ubiquitinated inclusions of spinal motor neurons and glial cells is characteristic of amyotrophic lateral sclerosis (ALS) pathology. Recent evidence suggests that TDP-43 pathology is common to sporadic ALS...

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Main Authors: Turner, Bradley J, Bäumer, Dirk, Parkinson, Nicholas J, Scaber, Jakub, Ansorge, Olaf, Talbot, Kevin
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583980/
https://ncbi.nlm.nih.gov/pubmed/18957104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-9-104
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