Leukocyte integrin signaling regulates FOXP1 gene expression via FOXP1-IT1 long non-coding RNA-mediated IRAK1 pathway

Leukocyte integrin-dependent downregulation of the transcription factor FOXP1 is required for monocyte differentiation and macrophage functions, but the precise gene regulatory mechanism is unknown. Here, we identify multi-promoter structure (P1, P2, and P3) of the human FOXP1 gene. Clustering of th...

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Detaylı Bibliyografya
Yayımlandı:Biochim Biophys Acta Gene Regul Mech
Asıl Yazarlar: Shi, Can, Miley, Jessica, Nottingham, Alison, Morooka, Toshifumi, Prosdocimo, Domenick A., Simon, Daniel I.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492945/
https://ncbi.nlm.nih.gov/pubmed/30831269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagrm.2019.02.008
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