Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα

Inflammation and thrombosis occur together in many diseases. The leukocyte integrin Mac-1 (also known as integrin α(M)β(2), or CD11b/CD18) is crucial for leukocyte recruitment to the endothelium, and Mac-1 engagement of platelet GPIbα is required for injury responses in diverse disease models. Howev...

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Publicado en:Nat Commun
Main Authors: Wang, Yunmei, Gao, Huiyun, Shi, Can, Erhardt, Paul W., Pavlovsky, Alexander, A. Soloviev, Dmitry, Bledzka, Kamila, Ustinov, Valentin, Zhu, Liang, Qin, Jun, Munday, Adam D., Lopez, Jose, Plow, Edward, Simon, Daniel I.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477519/
https://ncbi.nlm.nih.gov/pubmed/28555620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15559
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