IFIT1 Exerts Opposing Regulatory Effects on the Inflammatory and Interferon Gene Programs in LPS-Activated Human Macrophages

Activation of the TLR4 signaling pathway by lipopoly-saccharide (LPS) leads to induction of both inflammatory and interferon-stimulated genes, but the mechanisms through which these coordinately activated transcriptional programs are balanced to promote an optimal innate immune response remain poorl...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: John, Sinu P., Sun, Jing, Carlson, Rebecca J., Cao, Binh, Bradfield, Clinton J., Song, Jian, Smelkinson, Margery, Fraser, Iain D.C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492923/
https://ncbi.nlm.nih.gov/pubmed/30282041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.09.002
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