5-Azacytidine modulates interferon regulatory factor 1 in macrophages to exert a cardioprotective effect

Macrophages are actively involved in inflammatory responses during the progression of cardiac injury, including myocardial infarction (MI). A previous study showed that 5-azacytidine (5AZ), a DNA methylation inhibitor, can ameliorate cardiac injury by shifting macrophages toward an anti-inflammatory...

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Udgivet i:Sci Rep
Main Authors: Jeong, Hye-yun, Kang, Wan Seok, Hong, Moon Hwa, Jeong, Hae Chang, Shin, Myun-Geun, Jeong, Myung Ho, Kim, Yong Sook, Ahn, Youngkeun
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4625165/
https://ncbi.nlm.nih.gov/pubmed/26510961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15768
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