PRAS40 alleviates neurotoxic prion peptide‐induced apoptosis via mTOR‐AKT signaling

AIMS: The proline‐rich Akt substrate of 40‐kDa (PRAS40) protein is a direct inhibitor of mTORC1 and an interactive linker between the Akt and mTOR pathways. The mammalian target of rapamycin (mTOR) is considered to be a central regulator of cell growth and metabolism. Several investigations have dem...

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Veröffentlicht in:CNS Neurosci Ther
Hauptverfasser: Yang, Wei, Yang, Li‐Feng, Song, Zhi‐Qi, Shah, Syed Zahid Ali, Cui, Yong‐Yong, Li, Chao‐Si, Zhao, Hua‐Fen, Gao, Hong‐Li, Zhou, Xiang‐Mei, Zhao, De‐Ming
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492730/
https://ncbi.nlm.nih.gov/pubmed/28294542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12685
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