Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma

BACKGROUND: Although mutated HLA ligands are considered ideal cancer-specific immunotherapy targets, evidence for their presentation is lacking in hepatocellular carcinomas (HCCs). Employing a unique multi-omics approach comprising a neoepitope identification pipeline, we assessed exome-derived muta...

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Bibliografiske detaljer
Udgivet i:Genome Med
Main Authors: Löffler, Markus W., Mohr, Christopher, Bichmann, Leon, Freudenmann, Lena Katharina, Walzer, Mathias, Schroeder, Christopher M., Trautwein, Nico, Hilke, Franz J., Zinser, Raphael S., Mühlenbruch, Lena, Kowalewski, Daniel J., Schuster, Heiko, Sturm, Marc, Matthes, Jakob, Riess, Olaf, Czemmel, Stefan, Nahnsen, Sven, Königsrainer, Ingmar, Thiel, Karolin, Nadalin, Silvio, Beckert, Stefan, Bösmüller, Hans, Fend, Falko, Velic, Ana, Maček, Boris, Haen, Sebastian P., Buonaguro, Luigi, Kohlbacher, Oliver, Stevanović, Stefan, Königsrainer, Alfred, Rammensee, Hans-Georg
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492406/
https://ncbi.nlm.nih.gov/pubmed/31039795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-019-0636-8
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