Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma

BACKGROUND: Although mutated HLA ligands are considered ideal cancer-specific immunotherapy targets, evidence for their presentation is lacking in hepatocellular carcinomas (HCCs). Employing a unique multi-omics approach comprising a neoepitope identification pipeline, we assessed exome-derived muta...

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Detalhes bibliográficos
Publicado no:Genome Med
Main Authors: Löffler, Markus W., Mohr, Christopher, Bichmann, Leon, Freudenmann, Lena Katharina, Walzer, Mathias, Schroeder, Christopher M., Trautwein, Nico, Hilke, Franz J., Zinser, Raphael S., Mühlenbruch, Lena, Kowalewski, Daniel J., Schuster, Heiko, Sturm, Marc, Matthes, Jakob, Riess, Olaf, Czemmel, Stefan, Nahnsen, Sven, Königsrainer, Ingmar, Thiel, Karolin, Nadalin, Silvio, Beckert, Stefan, Bösmüller, Hans, Fend, Falko, Velic, Ana, Maček, Boris, Haen, Sebastian P., Buonaguro, Luigi, Kohlbacher, Oliver, Stevanović, Stefan, Königsrainer, Alfred, Rammensee, Hans-Georg
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492406/
https://ncbi.nlm.nih.gov/pubmed/31039795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-019-0636-8
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