Cyclosporine A sensitizes lung cancer cells to crizotinib through inhibition of the Ca2(+)/calcineurin/Erk pathway

BACKGROUND: Crizotinib has potent anti-tumor activity in patients with advanced MET-amplified non-small cell lung cancer (NSCLC). However, the therapeutic effect is still not satisfying. Thus, developing approaches that improve the efficacy of crizotinib remains a significant challenge. METHODS: MET...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Liu, Zhen, Jiang, Liming, Li, Yiran, Xie, Binbin, Xie, Jiansheng, Wang, Zhanggui, Zhou, Xiaoyun, Jiang, Hanliang, Fang, Yong, Pan, Hongming, Han, Weidong
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491942/
https://ncbi.nlm.nih.gov/pubmed/30879923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.03.019
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