Preclinical immunogenicity and safety of the cGMP-grade placental malaria vaccine PRIMVAC

BACKGROUND: VAR2CSA is the lead antigen for developing a vaccine that would protect pregnant women against placental malaria. A multi-system feasibility study has identified E. coli as a suitable bacterial expression platform allowing the production of recombinant VAR2CSA-DBL1x-2x (PRIMVAC) to envis...

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發表在:EBioMedicine
Main Authors: Chêne, Arnaud, Gangnard, Stéphane, Guadall, Anna, Ginisty, Hervé, Leroy, Odile, Havelange, Nicolas, Viebig, Nicola K., Gamain, Benoît
格式: Artigo
語言:Inglês
出版: Elsevier 2019
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Research paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491931/
https://ncbi.nlm.nih.gov/pubmed/30885725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.03.010
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