Gene signatures of quiescent glioblastoma cells reveal mesenchymal shift and interactions with niche microenvironment

BACKGROUND: Glioblastoma (GBM), a highly malignant brain tumor, invariably recurs after therapy. Quiescent GBM cells represent a potential source of tumor recurrence, but little is known about their molecular underpinnings. METHODS: Patient-derived GBM cells were engineered by CRISPR/Cas9-assisted k...

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Veröffentlicht in:EBioMedicine
Hauptverfasser: Tejero, Rut, Huang, Yong, Katsyv, Igor, Kluge, Michael, Lin, Jung-Yi, Tome-Garcia, Jessica, Daviaud, Nicolas, Wang, Yuanshuo, Zhang, Bin, Tsankova, Nadejda M., Friedel, Caroline C., Zou, Hongyan, Friedel, Roland H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
Schlagworte:
Research paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491796/
https://ncbi.nlm.nih.gov/pubmed/30952620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.03.064
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