Therminator DNA Polymerase: Modified Nucleotides and Unnatural Substrates

A variant of 9°N DNA polymerase [Genbank ID (AAA88769.1)] with three mutations (D141A, E143A, A485L) and commercialized under the name “Therminator DNA polymerase” has the ability to incorporate a variety of modified nucleotide classes. This Review focuses on how Therminator DNA Polymerase has enabl...

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Détails bibliographiques
Publié dans:Front Mol Biosci
Auteurs principaux: Gardner, Andrew F., Jackson, Kiserian M., Boyle, Madeleine M., Buss, Jackson A., Potapov, Vladimir, Gehring, Alexandra M., Zatopek, Kelly M., Corrêa Jr., Ivan R., Ong, Jennifer L., Jack, William E.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2019
Sujets:
Molecular Biosciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491775/
https://ncbi.nlm.nih.gov/pubmed/31069234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2019.00028
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