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Chimeric Mouse Model for MRI Contrast Agent Evaluation
PURPOSE: While rodents are the primary animal models for contrast agent evaluation, rodents can potentially misrepresent human organ clearance of newly developed contrast agents. For example, Gd-BOPTA has ~50% hepatic clearance in rodents, but ~5% in humans. This study demonstrates the benefit of ch...
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| Veröffentlicht in: | Magn Reson Med |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6491262/ https://ncbi.nlm.nih.gov/pubmed/30874333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mrm.27730 |
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