Early existence and biochemical evolution characterise acutely synaptotoxic PrP(Sc)

Although considerable evidence supports that misfolded prion protein (PrP(Sc)) is the principal component of “prions”, underpinning both transmissibility and neurotoxicity, clear consensus around a number of fundamental aspects of pathogenesis has not been achieved, including the time of appearance...

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Dades bibliogràfiques
Publicat a:PLoS Pathog
Autors principals: Foliaki, Simote Totauhelotu, Lewis, Victoria, Islam, Abu Mohammed Taufiqual, Ellett, Laura Jane, Senesi, Matteo, Finkelstein, David Isaac, Roberts, Blaine, Lawson, Victoria A., Adlard, Paul Anthony, Collins, Steven John
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6490942/
https://ncbi.nlm.nih.gov/pubmed/30970042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007712
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