Early existence and biochemical evolution characterise acutely synaptotoxic PrP(Sc)

Although considerable evidence supports that misfolded prion protein (PrP(Sc)) is the principal component of “prions”, underpinning both transmissibility and neurotoxicity, clear consensus around a number of fundamental aspects of pathogenesis has not been achieved, including the time of appearance...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Foliaki, Simote Totauhelotu, Lewis, Victoria, Islam, Abu Mohammed Taufiqual, Ellett, Laura Jane, Senesi, Matteo, Finkelstein, David Isaac, Roberts, Blaine, Lawson, Victoria A., Adlard, Paul Anthony, Collins, Steven John
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6490942/
https://ncbi.nlm.nih.gov/pubmed/30970042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007712
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