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Tetramethylpyrazine attenuated bupivacaine-induced neurotoxicity in SH-SY5Y cells through regulating apoptosis, autophagy and oxidative damage

Background: Bupivacaine (BUP) acts as a local anesthetic, which is extensively used for clinical patients but could generate neurotoxicity in neurons. Tetramethylpyrazine (TET) exhibits strong neuron protective effects against neurotoxicity. Hence, we investigate the effect of TET on BUP-induced neu...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Wang, Shouliang, Xia, Bin, Qiao, Zonglei, Duan, Lian, Wang, Gongming, Meng, Wenjun, Liu, Zhifei, Wang, Yu, Zhang, Mengyuan
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6489565/
https://ncbi.nlm.nih.gov/pubmed/31114159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S196172
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