Tetramethylpyrazine attenuated bupivacaine-induced neurotoxicity in SH-SY5Y cells through regulating apoptosis, autophagy and oxidative damage

Background: Bupivacaine (BUP) acts as a local anesthetic, which is extensively used for clinical patients but could generate neurotoxicity in neurons. Tetramethylpyrazine (TET) exhibits strong neuron protective effects against neurotoxicity. Hence, we investigate the effect of TET on BUP-induced neu...

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Enregistré dans:
Détails bibliographiques
Publié dans:Drug Des Devel Ther
Auteurs principaux: Wang, Shouliang, Xia, Bin, Qiao, Zonglei, Duan, Lian, Wang, Gongming, Meng, Wenjun, Liu, Zhifei, Wang, Yu, Zhang, Mengyuan
Format: Artigo
Langue:Inglês
Publié: Dove 2019
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6489565/
https://ncbi.nlm.nih.gov/pubmed/31114159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S196172
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