Tetramethylpyrazine attenuated bupivacaine-induced neurotoxicity in SH-SY5Y cells through regulating apoptosis, autophagy and oxidative damage

Background: Bupivacaine (BUP) acts as a local anesthetic, which is extensively used for clinical patients but could generate neurotoxicity in neurons. Tetramethylpyrazine (TET) exhibits strong neuron protective effects against neurotoxicity. Hence, we investigate the effect of TET on BUP-induced neu...

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Bibliografiske detaljer
Udgivet i:Drug Des Devel Ther
Main Authors: Wang, Shouliang, Xia, Bin, Qiao, Zonglei, Duan, Lian, Wang, Gongming, Meng, Wenjun, Liu, Zhifei, Wang, Yu, Zhang, Mengyuan
Format: Artigo
Sprog:Inglês
Udgivet: Dove 2019
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6489565/
https://ncbi.nlm.nih.gov/pubmed/31114159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S196172
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