CRISPR/Cas9-mediated disruption of SHANK3 in monkey leads to drug-treatable autism-like symptoms

Monogenic mutations in the SHANK3 gene, which encodes a postsynaptic scaffold protein, play a causative role in autism spectrum disorder (ASD). Although a number of mouse models with Shank3 mutations have been valuable for investigating the pathogenesis of ASD, species-dependent differences in behav...

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Veröffentlicht in:Hum Mol Genet
Hauptverfasser: Tu, Zhuchi, Zhao, Hui, Li, Bang, Yan, Sen, Wang, Lu, Tang, Yongjin, Li, Zhujun, Bai, Dazhang, Li, Caijuan, Lin, Yingqi, Li, Yuefeng, Liu, Jianrong, Xu, Hao, Guo, Xiangyu, Jiang, Yong-hui, Zhang, Yong Q, Li, Xiao-Jiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6489410/
https://ncbi.nlm.nih.gov/pubmed/30329048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy367
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