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Inferring cancer dependencies on metabolic genes from large-scale genetic screens
BACKGROUND: Cancer cells reprogram their metabolism to survive and propagate. Thus, targeting metabolic rewiring in tumors is a promising therapeutic strategy. Genome-wide RNAi and CRISPR screens are powerful tools for identifying genes essential for cancer cell proliferation and survival. Integrati...
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| Publié dans: | BMC Biol |
|---|---|
| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6489231/ https://ncbi.nlm.nih.gov/pubmed/31039782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-019-0654-4 |
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