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NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism

NADPH donates high energy electrons for antioxidant defense and reductive biosynthesis. Cytosolic NADP is recycled to NADPH by the oxidative pentose phosphate pathway (oxPPP), malic enzyme 1 (ME1) and isocitrate dehydrogenase 1 (IDH1). Here we show that any one of these routes can support cell growt...

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Bibliografiske detaljer
Udgivet i:Nat Metab
Main Authors: Chen, Li, Zhang, Zhaoyue, Hoshino, Atsushi, Zheng, Henry D., Morley, Michael, Arany, Zoltan, Rabinowitz, Joshua D.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6489125/
https://ncbi.nlm.nih.gov/pubmed/31058257
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