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Oxidative pentose phosphate pathway and glucose anaplerosis support maintenance of mitochondrial NADPH pool under mitochondrial oxidative stress

Mitochondrial NADPH protects cells against mitochondrial oxidative stress by serving as an electron donor to antioxidant defense systems. However, due to technical challenges, it still remains unknown as to the pool size of mitochondrial NADPH, its dynamics, and NADPH/NADP(+) ratio. Here, we have sy...

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書目詳細資料
發表在:Bioeng Transl Med
Main Authors: Moon, Sun Jin, Dong, Wentao, Stephanopoulos, Gregory N., Sikes, Hadley D.
格式: Artigo
語言:Inglês
出版: John Wiley & Sons, Inc. 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7510474/
https://ncbi.nlm.nih.gov/pubmed/33005744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/btm2.10184
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