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Oxidative pentose phosphate pathway and glucose anaplerosis support maintenance of mitochondrial NADPH pool under mitochondrial oxidative stress

Mitochondrial NADPH protects cells against mitochondrial oxidative stress by serving as an electron donor to antioxidant defense systems. However, due to technical challenges, it still remains unknown as to the pool size of mitochondrial NADPH, its dynamics, and NADPH/NADP(+) ratio. Here, we have sy...

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Detalhes bibliográficos
Publicado no:Bioeng Transl Med
Main Authors: Moon, Sun Jin, Dong, Wentao, Stephanopoulos, Gregory N., Sikes, Hadley D.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7510474/
https://ncbi.nlm.nih.gov/pubmed/33005744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/btm2.10184
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