Combinations of four or more CpGs methylation present equivalent predictive value for MGMT expression and temozolomide therapeutic prognosis in gliomas

AIMS: The pyrosequencing (PSQ) has been regarded as the gold standard for MGMT promoter methylation testing in gliomas. However, various CpG combinations are currently used in clinical practice. We aimed to clarify how and how many CpGs combined is robust enough to predict MGMT mRNA expression and t...

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Gepubliceerd in:CNS Neurosci Ther
Hoofdauteurs: Chai, Rui‐Chao, Zhang, Ke‐Nan, Liu, Yu‐Qing, Wu, Fan, Zhao, Zheng, Wang, Kuan‐Yu, Jiang, Tao, Wang, Yong‐Zhi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2018
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Original Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488893/
https://ncbi.nlm.nih.gov/pubmed/30117294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.13040
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