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Crystal structure of the Lin28-interacting module of human terminal uridylyltransferase that regulates let-7 expression
Lin28-dependent oligo-uridylylation of precursor let-7 (pre-let-7) by terminal uridylyltransferase 4/7 (TUT4/7) represses let-7 expression by blocking Dicer processing, and regulates cell differentiation and proliferation. The interaction between the Lin28:pre-let-7 complex and the N-terminal Lin28-...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6488673/ https://ncbi.nlm.nih.gov/pubmed/31036859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09966-5 |
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