Eomes transcription factor is required for the development and differentiation of invariant NKT cells

Eomes regulates the differentiation of CD8(+) T cells into effector and memory phases. However, its role in invariant (i)NKT cells remains unknown. Here, we show the impact of Eomes on iNKT cells in the thymus and peripheral tissue using conditional knockout (Eomes-cKO) mice. In the thymus, CD1d-tet...

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Bibliographic Details
Published in:Commun Biol
Main Authors: Shimizu, Kanako, Sato, Yusuke, Kawamura, Masami, Nakazato, Hiroshi, Watanabe, Takashi, Ohara, Osamu, Fujii, Shin-ichiro
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488575/
https://ncbi.nlm.nih.gov/pubmed/31044175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0389-3
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