Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging

OBJECTIVE: Nitisinone induced hypertyrosinaemia is a concern in patients with Alkaptonuria (AKU). It has been suggested that this may alter neurotransmitter metabolism, specifically dopamine and serotonin. Herein mass spectrometry imaging (MSI) is used for the direct measurement of 2,4-diphenyl-pyra...

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發表在:Metabolomics
Main Authors: Davison, A. S., Strittmatter, N., Sutherland, H., Hughes, A. T., Hughes, J., Bou-Gharios, G., Milan, A. M., Goodwin, R. J. A., Ranganath, L. R., Gallagher, J. A.
格式: Artigo
語言:Inglês
出版: Springer US 2019
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488549/
https://ncbi.nlm.nih.gov/pubmed/31037385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11306-019-1531-4
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