Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging

OBJECTIVE: Nitisinone induced hypertyrosinaemia is a concern in patients with Alkaptonuria (AKU). It has been suggested that this may alter neurotransmitter metabolism, specifically dopamine and serotonin. Herein mass spectrometry imaging (MSI) is used for the direct measurement of 2,4-diphenyl-pyra...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Metabolomics
Auteurs principaux: Davison, A. S., Strittmatter, N., Sutherland, H., Hughes, A. T., Hughes, J., Bou-Gharios, G., Milan, A. M., Goodwin, R. J. A., Ranganath, L. R., Gallagher, J. A.
Format: Artigo
Langue:Inglês
Publié: Springer US 2019
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488549/
https://ncbi.nlm.nih.gov/pubmed/31037385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11306-019-1531-4
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires