Quantification of the flux of tyrosine pathway metabolites during nitisinone treatment of Alkaptonuria

Nitisinone decreases homogentisic acid (HGA) in Alkaptonuria (AKU) by inhibiting the tyrosine metabolic pathway in humans. The effect of different daily doses of nitisinone on circulating and 24 h urinary excretion of phenylalanine (PA), tyrosine (TYR), hydroxyphenylpyruvate (HPPA), hydroxyphenyllac...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Milan, A. M., Hughes, A. T., Davison, A. S., Khedr, M., Rovensky, J., Psarelli, E. E., Cox, T. F., Rhodes, N. P., Gallagher, J. A., Ranganath, L. R.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624311/
https://ncbi.nlm.nih.gov/pubmed/31296884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46033-x
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