Quantification of the flux of tyrosine pathway metabolites during nitisinone treatment of Alkaptonuria

Nitisinone decreases homogentisic acid (HGA) in Alkaptonuria (AKU) by inhibiting the tyrosine metabolic pathway in humans. The effect of different daily doses of nitisinone on circulating and 24 h urinary excretion of phenylalanine (PA), tyrosine (TYR), hydroxyphenylpyruvate (HPPA), hydroxyphenyllac...

詳細記述

保存先:
書誌詳細
出版年:Sci Rep
主要な著者: Milan, A. M., Hughes, A. T., Davison, A. S., Khedr, M., Rovensky, J., Psarelli, E. E., Cox, T. F., Rhodes, N. P., Gallagher, J. A., Ranganath, L. R.
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624311/
https://ncbi.nlm.nih.gov/pubmed/31296884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46033-x
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