Quantification of the flux of tyrosine pathway metabolites during nitisinone treatment of Alkaptonuria

Nitisinone decreases homogentisic acid (HGA) in Alkaptonuria (AKU) by inhibiting the tyrosine metabolic pathway in humans. The effect of different daily doses of nitisinone on circulating and 24 h urinary excretion of phenylalanine (PA), tyrosine (TYR), hydroxyphenylpyruvate (HPPA), hydroxyphenyllac...

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Publicado en:Sci Rep
Main Authors: Milan, A. M., Hughes, A. T., Davison, A. S., Khedr, M., Rovensky, J., Psarelli, E. E., Cox, T. F., Rhodes, N. P., Gallagher, J. A., Ranganath, L. R.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624311/
https://ncbi.nlm.nih.gov/pubmed/31296884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46033-x
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