Predicting synthetic lethal interactions using conserved patterns in protein interaction networks

In response to a need for improved treatments, a number of promising novel targeted cancer therapies are being developed that exploit human synthetic lethal interactions. This is facilitating personalised medicine strategies in cancers where specific tumour suppressors have become inactivated. Mainl...

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Udgivet i:PLoS Comput Biol
Main Authors: Benstead-Hume, Graeme, Chen, Xiangrong, Hopkins, Suzanna R., Lane, Karen A., Downs, Jessica A., Pearl, Frances M. G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488098/
https://ncbi.nlm.nih.gov/pubmed/30995217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006888
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