Flow-enhanced vascularization and maturation of kidney organoids in vitro

Kidney organoids derived from human pluripotent stem cells exhibit glomerular- and tubular-like compartments that are largely avascular and immature in static culture. Here, we report an in vitro method for culturing kidney organoids under flow on millifluidic chips, which greatly expands their endo...

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Udgivet i:Nat Methods
Main Authors: Homan, Kimberly A., Gupta, Navin, Kroll, Katharina T., Kolesky, David B., Skylar-Scott, Mark, Miyoshi, Tomoya, Mau, Donald, Valerius, M. Todd, Ferrante, Thomas, Bonventre, Joseph V., Lewis, Jennifer A., Morizane, Ryuji
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488032/
https://ncbi.nlm.nih.gov/pubmed/30742039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-019-0325-y
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