The PPARγ Agonist Pioglitazone Fails to Alter the Abuse Potential of Heroin, But Does Reduce Heroin Craving and Anxiety

Possibly through its effects on glia, the peroxisome proliferator-activated gamma receptor (PPARγ) agonist pioglitazone (PIO) has been shown to alter the effects of heroin in preclinical models. Until now, these results have not been assessed in humans. Heroin-dependent participants were randomized...

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Vydáno v:J Psychoactive Drugs
Hlavní autoři: Jones, Jermaine D., Bisaga, Adam, Metz, Verena E., Manubay, Jeanne M., Mogali, Shanthi, Ciccocioppo, Roberto, Madera, Gabriela, Doernberg, Molly, Comer, Sandra D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487639/
https://ncbi.nlm.nih.gov/pubmed/30204554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/02791072.2018.1508789
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