The effects of pioglitazone, a PPARγ receptor agonist, on the abuse liability of oxycodone among nondependent opioid users

AIMS: Activation of PPARγ by pioglitazone (PIO) has shown some efficacy in attenuating addictive-like responses in laboratory animals. The ability of PIO to alter the effects of opioids in humans has not been characterized in a controlled laboratory setting. The proposed investigation sought to exam...

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Publicado en:Physiol Behav
Autores principales: Jones, Jermaine D., Sullivan, Maria A., Manubay, Jeanne M., Mogali, Shanthi, Metz, Verena E., Ciccocioppo, Roberto, Comer, Sandra D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444321/
https://ncbi.nlm.nih.gov/pubmed/26455893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.physbeh.2015.10.006
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