PIK3CA activating mutations are associated with more disseminated disease at presentation and earlier recurrence in glioblastoma

Phosphatidylinositol 3-kinase signaling promotes cell growth and survival and is frequently activated in infiltrative gliomas. Activating mutations in PIK3CA gene are observed in 6–15% of glioblastomas, although their clinical significance is largely undescribed. The objective of this study was to e...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Tanaka, Shota, Batchelor, Tracy T., Iafrate, A. John, Dias-Santagata, Dora, Borger, Darrell R., Ellisen, Leif W., Yang, Daniel, Louis, David N., Cahill, Daniel P., Chi, Andrew S.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487518/
https://ncbi.nlm.nih.gov/pubmed/31036078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0720-8
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