Genetically distinct glioma stem-like cell xenografts established from paired glioblastoma samples harvested before and after molecularly targeted therapy

Intratumoural heterogeneity underlies tumour escape from molecularly targeted therapy in glioblastoma. A cell-based model preserving the evolving molecular profiles of a tumour during treatment is key to understanding the recurrence mechanisms and development of strategies to overcome resistance. In...

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Publicado no:Sci Rep
Main Authors: Tanaka, Shota, Luk, Samantha, Kiyokawa, Juri, Onozato, Maristela L., Iafrate, A. John, Shah, Khalid, Martuza, Robert L., Rabkin, Samuel D., Batchelor, Tracy T., Cahill, Daniel P., Chi, Andrew S., Wakimoto, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6333836/
https://ncbi.nlm.nih.gov/pubmed/30644426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37437-2
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