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Ultra-potent vinblastine analogues improve on-target activity of the parent microtubulin-targeting compound
In recent efforts, several C20’ urea vinblastine analogues were discovered that displayed remarkable potency against vinblastine-sensitive tumor cell lines (IC(50) 50–75 pM), being roughly 100-fold more potent than vinblastine, and that exhibited decreased susceptibility to Pgp efflux-derived resist...
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| 出版年: | Bioorg Med Chem Lett |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6487230/ https://ncbi.nlm.nih.gov/pubmed/30952593 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.03.036 |
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