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Potent Vinblastine C20′ Ureas Displaying Additionally Improved Activity Against a Vinblastine-Resistant Cancer Cell Line
[Image: see text] A series of disubstituted C20′-urea derivatives of vinblastine were prepared from 20′-aminovinblastine that was made accessible through a unique Fe(III)/NaBH(4)-mediated alkene functionalization reaction of anhydrovinblastine. Three analogues were examined across a panel of 15 huma...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Chemical Society
2013
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3821838/ https://ncbi.nlm.nih.gov/pubmed/24223237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400281w |
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