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A Remarkable Series of Vinblastine Analogues Displaying Enhanced Activity and an Unprecedented Tubulin Binding Steric Tolerance: C20' Urea Derivatives

A systematic series of previously inaccessible key C20' urea and thiourea derivatives of vinblastine were prepared from 20'-aminovinblastine that was made accessible through a unique Fe(III)/NaBH(4)-mediated alkene functionalization reaction of anhydrovinblastine. Their examination defined...

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Detalhes bibliográficos
Main Authors: Leggans, Erick K., Duncan, Katharine K., Barker, Timothy J., Schleicher, Kristin D., Boger, Dale L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574233/
https://ncbi.nlm.nih.gov/pubmed/23244701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3015684
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