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Cross-interaction of tau PET tracers with monoamine oxidase B: evidence from in silico modelling and in vivo imaging

PURPOSE: Several tracers have been designed for tracking the abnormal accumulation of tau pathology in vivo. Recently, concerns have been raised about the sources of off-target binding for these tracers; inconclusive data propose binding for some tracers to monoamine oxidase B (MAO-B). METHODS: Mole...

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Bibliografski detalji
Izdano u:Eur J Nucl Med Mol Imaging
Glavni autori: Murugan, N. Arul, Chiotis, Konstantinos, Rodriguez-Vieitez, Elena, Lemoine, Laetitia, Ågren, Hans, Nordberg, Agneta
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486902/
https://ncbi.nlm.nih.gov/pubmed/30919054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-019-04305-8
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