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Extreme mechanical diversity of human telomeric DNA revealed by fluorescence-force spectroscopy

G-quadruplexes (GQs) can adopt diverse structures and are functionally implicated in transcription, replication, translation, and maintenance of telomere. Their conformational diversity under physiological levels of mechanical stress, however, is poorly understood. We used single-molecule fluorescen...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Mitra, Jaba, Makurath, Monika A., Ngo, Thuy T. M., Troitskaia, Alice, Chemla, Yann R., Ha, Taekjip
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486787/
https://ncbi.nlm.nih.gov/pubmed/30944218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1815162116
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