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Locus coeruleus toggles reciprocal prefrontal firing to reinstate fear

The medial prefrontal cortex (mPFC) plays an essential role in regulating emotion, including inhibiting fear when danger has passed. The extinction of fear, however, is labile and a number of factors, including stress, cause extinguished fear to relapse. Here we show that fear relapse in rats limits...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Giustino, Thomas F., Fitzgerald, Paul J., Ressler, Reed L., Maren, Stephen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486780/
https://ncbi.nlm.nih.gov/pubmed/30971490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814278116
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