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Myosin Va transport of liposomes in three-dimensional actin networks is modulated by actin filament density, position, and polarity

The cell’s dense 3D actin filament network presents numerous challenges to vesicular transport by teams of myosin Va (MyoVa) molecular motors. These teams must navigate their cargo through diverse actin structures ranging from Arp2/3-branched lamellipodial networks to the dense, unbranched cortical...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Lombardo, Andrew T., Nelson, Shane R., Kennedy, Guy G., Trybus, Kathleen M., Walcott, Sam, Warshaw, David M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486769/
https://ncbi.nlm.nih.gov/pubmed/30967504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1901176116
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