Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53

A population-restricted single-nucleotide coding region polymorphism (SNP) at codon 47 exists in the human TP53 gene (P47S, hereafter P47 and S47). In studies aimed at identifying functional differences between these variants, we found that the African-specific S47 variant associates with an impaire...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Leu, Julia I-Ju, Murphy, Maureen E., George, Donna L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2019
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486733/
https://ncbi.nlm.nih.gov/pubmed/30962386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1821277116
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