The WD40 domain of FBXW7 is a poly(ADP-ribose)-binding domain that mediates the early DNA damage response

FBXW7, a classic tumor suppressor, is a substrate recognition subunit of the Skp1-cullin-F-box (SCF) ubiquitin ligase that targets oncoproteins for ubiquitination and degradation. We recently found that FBXW7 is recruited to DNA damage sites to facilitate nonhomologous end-joining (NHEJ). The detail...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Zhang, Qiang, Mady, Ahmed S A, Ma, Yuanyuan, Ryan, Caila, Lawrence, Theodore S, Nikolovska-Coleska, Zaneta, Sun, Yi, Morgan, Meredith A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486556/
https://ncbi.nlm.nih.gov/pubmed/30722038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz058
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